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N Engl J Med 383:14251435 McMurray JJV, Solomon SD, Inzucchi SE, Kber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Blohlvek J, Bhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukt A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, OMeara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjstrand M, Langkilde AM (2019) DAPA-HF Trial Committees and Investigators
So, they changed the game
Movement & Exercise: Regular strength training and aerobic activity boost insulin sensitivity and metabolic health, complementing berberines role
For many patients, particularly those with modest glycaemic targets or those experiencing significant weight loss, 5 mg may serve as an effective maintenance dose
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