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Previous studies have demonstrated that chronic endotoxin exposure is related to NASH (Verdam et al., 2011) and is likely due to the activation of TLR4 in immune cells
This is important to note if youre taking the contraceptive pill, as you may need to use a barrier method, like condoms, to prevent pregnancy
Always consult with your healthcare provider before making any changes to your medication regimen
Another limitation is that the pharmacokinetic assessments on the 10th day of dosing in the current trials do not fully reflect the steady-state situation achieved with continuous once-daily dosing in the clinical setting because of the long half-life of approximately 1 week for oral semaglutide
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