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Genetic studies often suffer from small effect sizes, phenotypic heterogeneity, and population stratification, limiting reproducibility across diverse cohorts
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Patients typically lose 10 to 15 percent of body weight on semaglutide at the higher doses, with strong improvements in A1C, blood pressure, and cardiovascular risk markers
There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]
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