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doi: 10.1080/15548627.2016.1187366 Summary Keywords diabetic kidney disease, regulated cell death, tubular epithelial cell, tubular injury, crosstalk Citation Sun H, Chen W, Huang H, Chen L, He S, Wang X and Xie S (2026) Tubular injury in diabetic kidney disease: a focus on regulated cell death
Typically, the E3 ubiquitin ligase complex comprised of Kelch-like ECH-associated protein 1-Cullin 3-Ring box 1 (KEAP1-CUL3-RBX1), S-phase kinase associated protein 1-Cullin 1-Rbx1/-transducin repeat-containing protein (SCF/-TrCP), and synonymin/Hrd1, continuously degrades Nrf2 proteasomes, maintaining Nrf2 at a low expression level [64]
Some researchers have explored its applications in chronic fatigue syndrome (CFS), fibromyalgia, and neurodegenerative conditions due to its ability to improve deep sleep and cellular recovery
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