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The supplement layer with the strongest PCOS-specific RCT evidence is the 40:1 myo-inositol to D-chiro-inositol ratio for insulin sensitivity and ovulation restoration (Nordio & Proietti 2012), spearmint tea for circulating androgens when hirsutism is a primary concern (Grant 2010), targeted omega-3 supplementation for the inflammatory and hyperandrogenic load (Phelan et al