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Risk factors for accelerated B12 depletion include prior gastric surgery, pernicious anemia history, metformin use, veganism or vegetarian diet, and genetic variants in B12 metabolism
The peptide carries a fatty-acid chain that binds albumin and extends its half-life, which supports once-weekly subcutaneous administration in clinical trials
In some cases, when patients are constipated, the laxative effect of sugar alcohols may be an advantage, but for most people that is not the case
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