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Description Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine, linked by an unusual -glutamyl bond that distinguishes it from standard peptide chains
& Fan, W
Recently Li et al., 2019 identified a potent GPX4 metastable site and obtained eight GPX4 metastable activators by structural analysis and computational design (Scarpellini et al., 2023)
Timely intervention with the antioxidant GSH to inhibit high glucose-induced PSC activation and proliferation via blocking the TGF pathway is important for the prophylaxis and treatment of diabetes and may help protect people at risk of T2DM from pancreatic fibrosis and subsequent -cell failure
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