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Both drugs may be prescribed for people with obesity with a body mass index (BMI) of 30 or higher and people who are overweight with a BMI of 27 or higher with weight-related medical conditions

Orlistat (available as Xenical on prescription or Alli from a pharmacy) is generally less likely to cause nausea than GLP-1 receptor agonists such as semaglutide or liraglutide, though it has its own gastrointestinal side effects including oily stools and faecal urgency

Determining the underlying hormone condition, if any, will help you and your doctor narrow down treatment options