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Common side effects of GLP-1R activation within the gastrointestinal tract also include nausea, vomiting, constipation, and diarrhea, due to the receptors role in modulating gastric emptying
But biology is complex
The discontinuation rate in clinical trials ranged between 20% and 50% within the first year, with GI intolerance being the primary reason
Those with prediabetes Emerging evidence suggests that GLP-1 drugs could help prevent or delay the onset of Type 2 diabetes in individuals with prediabetes by improving insulin sensitivity and promoting weight loss
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