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Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight
10.1016/j.drugalcdep.2012.03.004 Drug Alcohol Depend
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The interpretation of trial results should put into account real-world discontinuation rates and heterogeneity of patient populations
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