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Elevated glucose concentrations activate the RAAS, constricting efferent arterioles and thereby increasing intraglomerular pressure [25]
This suggests GLP-1 resistance emerges further downstream
Always consult with a qualified healthcare provider or pharmacist before starting, stopping, or changing any medication
As noted by others ( Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)
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