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137 In metastatic CRPC, coloss of TP53/RB1 and overexpression of SOX2 activate JAK1/STAT1, promoting lineage plasticity and transition to a stem-like, multilineage-resistant state
If neurological symptoms are present particularly gait disturbance, sensory ataxia, or progressive limb weakness urgent assessment should be arranged and intramuscular hydroxocobalamin treatment initiated without delay, in line with NICE CKS and BSH guidance on cobalamin and folate disorders
30 capsules Nutritional information Liposomal Vitamin C , thanks to its special formulation, offers superior absorption compared to traditional Vitamin C, boosting the immune system, reducing inflammation, and protecting cells from oxidative stress
Two different phase I studies have confirmed the safety and CNS uptake of glutathione after intranasal administration [209, 210]
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