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With B12, as with many nutrients, the goal is not as much as possible

the 250 to 500 mcg range is extrapolated from rat studies, not proven in humans

Ali II, DSouza C, Singh J, Adeghate E

Indications: attention-deficit disorders narcolepsy Contraindications: Lactation Contraindicated for long-term use for treating obesity (due to development of tolerance &/or drug dependence) Side Effects: anorexia dry mouth dizziness headaches hyperpyrexia hypertension insomnia nervousness palpitations / tachycardia weight loss Black Box Warnings: HIGH POTENTIAL FOR ABUSE Pharmacokinetics: Dexedrine - PO, completely absorbed in 3 hr