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Additional tyrosinase inhibitors with clinical evidence on melasma and/or PIH include azelaic acid [25, 27, 67, 90], kojic acid [27, 66, 90], cysteamine [7, 91,92,93], and several actives from licorice extracts such as glabridin, liquiritin, and isoliquiritin [27, 94], as well as resveratrol and some of its derivatives [73, 95]
doi: 10.1146/annurev-physiol-021115-105238 28 DicksonR
These supplements should work together with a balanced diet, regular exercise, managing stress, and getting enough sleep
So far, serious side effects havent been common, but heres what an early phase 2 study has shown: Pancreatitis: Happened in about 0.4% of people in the study Gallbladder problems: Reported in about 1.1% of participants Heart rhythm changes: Seen more often with retatrutide, about 6% compared to 3% with placebo Liver enzyme changes: Around 1% of participants had increases, but overall liver health stayed stable These results suggest a low but real chance of serious issues such as pancreatitis, gallbladder problems, severe GI events, and allergic reactions
