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Any disruption along this pathway can lead to deficiency regardless of dietary intake, which is why some patients need supplementation even when they eat B12-rich foods
In a randomised clinical trial involving five treatment arms with doses of between 2.5 g/day and 1000 g/day, Eussen [33] concluded that a dose of at least 600 g/day was required to obtain adequate results
Allergy to vitamin B12 is uncommon
2011 Nov;49(11):1877-82
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