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IS upregulates signal transducer and activator of transcription 3 (STAT3) phosphorylation, increasing production of TGF-1, monocyte chemoattractant protein-1 (MCP-1), and -smooth muscle actin (-SMA), participating in interstitial inflammation and renal fibrosis (116)

Benefits include: B12 helps convert the food you eat into glucose, which gives you energy

The gut and brain talk constantly along the vagus nerve and through immune, hormonal and short-chain-fatty-acid signals the microbiotagutbrain axis and a disturbed microbiome in IBS (which affects 1020% of people), SIBO , leaky gut or long COVID can cloud thinking

Funding This work was supported by the European Community under Innovative Medicines Initiative (IMI) Program (Grant No