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Combined with semaglutide (CagriSema), it demonstrated 20.4% weight loss in the Phase 3 REDEFINE 1 trial, approaching the efficacy of bariatric surgery

Meanwhile, the BODIPY-cholesterol efflux assay indicated that EX-4 treatment alone or cholesterol co-treatment dramatically increased cholesterol efflux from INS-1 cells compared with the single cholesterol stimulation group or the control group (Figure 1J)

Furthermore, facial flushing generally only occurs after consuming extremely high doses of niacin such as 500 mg or more which can usually only be reached in supplement form (15)

This strategy does not change how the medication works