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Phentermine and topiramate extended-release 22.5 mg/138 mg [a supra-therapeutic dose resulting in a phentermine and topiramate maximum concentration (Cmax) of 4-and 3-times higher than those at phentermine and topiramate extended-release 7.5 mg/46 mg, respectively] did not affect cardiac repolarization as measured by the change from baseline in QTc

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