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Clinical Trial Participation Phase 3 trials for Retatrutide include Canadian sites

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Rezaee et al., 2025)

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The Food and Drug Administration approved semaglutide for obesity treatment in 2021, making it the first FDA-approved weight management medication since 2014