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The upregulation of hepcidin inhibits the function of ferroportin, leading to intracellular iron accumulation (58), an increase in intracellular free iron levels, and subsequent lipid peroxidation and ferroptosis (59)
These hormones help regulate blood sugar and appetite
The affinity constant ( K d ) was determined by fitting the ligand titration curve in a single site-binding isotherm: where [S], substrate concentration
The use of two complementary peptides enables more complex experimental design compared to single-compound studies
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