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Proteostasis biomarkers, including HSP expression profiles, autophagy flux indicators, ubiquitinated protein accumulation, and p62/SQSTM1 levels, are increasingly informative regarding prognosis and therapeutic responsiveness

The pill form of semaglutide , marketed as Rybelsus, is approved for type 2 diabetes, but not yet for weight loss as Wegovy pills. Early research suggests the side effects are similar because the active ingredient is the same

In head-to-head trials, tirzepatide produced 20-22% weight loss compared to semaglutide's 15-18% across similar timeframes

While many drugs in this class were initially approved to treat type 2 diabetes, they have also been approved for weight loss