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Annals of Pharmacotherapy, 44 (5), 904909

[2] This may stimulate the production of second messengers like cAMP and IP3 (inositol trisphosphate), which could propagate the signal within the cell and possibly activate protein kinases that may phosphorylate target proteins and regulate cellular processes

Jagannatha Rao [cited 2021 Nov 24] 24

An uneven bite against it can gradually shift individual teeth, put extra strain on the jaw joint and worsen TMJ pain rather than relieve it, or simply fall out overnight, which rather defeats the point