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Phase 2 data (Jastreboff et al., NEJM 2023) showed mean pulse rate increases of approximately 3 to 5 beats per minute at higher doses, consistent with known GLP-1 receptor agonist pharmacology
A recent meta-analysis of Phase 3 trials reported increases in HR, based on single time point assessments, in the range of 14 bpm with both long- and short-acting GLP-1 RAs [15]
Conversely, adolescent GLU female offspring showed increased blood glucose levels 15 min after glucose injection
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