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Treatment of human and mouse small intestine organoid models with SCFAs increases the number of GLP-1-producing cells twofold 284 , and SCFA infusion activates colonic EECs to increase GLP-1 release in mice 281
The glucagon receptor activation in retatrutide creates a different side effect profile
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Vilsbll has received personal honoraria for consulting, lectures and/or for advisory board participation within the last 36 months from Amgen, AstraZeneca, Boehringer-Ingelheim Pharmaceuticals, Bristol-Myers Squibb, Eli Lilly, Janssen-Cilag, Merck Sharp & Dohme, Novo Nordisk, Sanofi-Aventis, and Zealand Pharma and has received unrestricted research grants from Novo Nordisk and the Novo Nordisk Foundation
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