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Additionally, VQ lacking the target small molecule (VQ-N) generated only low-level background signals and did not recapitulate the pronounced variant-specific peaks observed with Berberine-VQ-N 3 (NMe 2 ), supporting that the variant-specific RT-deletions primarily arise from target ligand-dependent binding (Supplementary Fig
The criteria to clinically diagnose a rapidly spreading pigmented lesion are [] Diffuse outline Sudden increase in size and extent Deepening of the pigment color of the lesion Raised lesion instead of a flat one Nodular, rough, and irregular surface
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