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Semaglutide (Ozempic, Wegovy) is a GLP-1 receptor agonist, while Tirzepatide (Mounjaro, Zepbound) binds with both receptors (GLP-1 and GIP) and thus tends to have more effects on weight loss than semaglutide alone
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In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group
Both are considered safe for shortterm, occasional use in pregnancy
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