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On the other hand, ERK showed reduced phosphorylation in GNE mutant cells even after IGF-1 treatment suggesting downregulation of the ERK pathway

Tyni T, Kivela T, Lappi M, Summanen P, Nikoskelainen E, Pihko H: Ophthalmologic findings in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation: a new type of hereditary metabolic chorioretinopathy

All studies were approved by and performed according to the ethical guidelines by the Chungbuk National University Animal Care Committee (CBNU-523-13-01)

Tirzepatide can be used safely in patients with Hashimoto's who meet obesity treatment criteria, provided thyroid function is optimized and contraindications are excluded (personal or family history of medullary thyroid carcinoma or MEN2)