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The standard NHS pattern is a loading phase (injections on alternate days for up to two weeks), then maintenance
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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007
Patients typically contact their plan administrator before the appointment to confirm what documentation will be needed
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