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Wegovy , which uses the same semaglutide molecule at higher weekly doses (up to 2.4 mg) and is approved by Health Canada specifically for chronic weight management, has no generic equivalent yet
Both NNC0090-2746 (107) and tirzepatide (63) delivered clinically meaningful improvements in glycemic control and body weight reduction in their phase 1 trials
Newsome, Jie Li Alimentary Pharmacology & Therapeutics .2025
In one human trial, a single injection elevated IGF-1 levels for 911 days above baseline
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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