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Its ability to cross the blood-brain barrier makes it an important tool for neurobiology and behavioral research
Since effectiveness of cannabinoid receptor antagonists is limited by brain penetration and neuropsychiatric side effects, perhaps using lower doses or agents with less access to the CNS in combination with NuSH mimetics would result in superior outcomes
Chang, Chung-Hsun et al
While B12 is water-soluble with no established upper safe limit (according to NHS and EFSA guidance), this does not preclude the possibility of adverse reactions, particularly from injectable forms
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