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These results are not unprecedentedour lab has shown that some RNA viruses target host mRNAs encoding isoforms of thioredoxin reductase via RNA:RNA antisense interactions, which, like proteolysis, would likely also result in host selenoprotein knockdown, but by a different mechanism ( Understanding why RNA viruses may have developed such strategies presents an interesting challenge for future research
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Activated T cells that upregulate Gln transporters also exhibit signs of GLS-dependent activity ( In the microenvironment of liver cancer tumors, Gln deficiency promotes the invasion of myeloid cells expressing the immunosuppressive receptor GPR109A, facilitating immune evasion
The Bigger Concern: Leaving a Deficiency Untreated When weighing the minimal risks of B12 injections, it helps to consider the well-documented risks of an untreated B12 deficiency
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