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Summary Melanotan-2 is a potent melanocortin agonist that darkens skin (via MC1R) and triggers erections by acting on central melanocortin pathways
Although current evidence is limited to case reports, these agents can be successfully integrated with existing protocols (biologics, antibiotics, or metformin)
The practical result is that tirzepatide tends to produce stronger appetite suppression, greater fat loss relative to lean mass, and improved metabolic markers compared to semaglutide at their respective optimal doses
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