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GLP-1 medications: Improve insulin sensitivity Enhance fat metabolism May support more flexible, responsive adipose tissue iv

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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

It functions similarly to CJC-1295 (without DAC), promoting physiologic GH pulses that support recovery, tissue repair, and systemic regeneration