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Notably, the oncogenic drivers prevalent in PDAC, such as mutant KRAS and loss of TP53 or SMAD4, intricately modulate key ferroptotic pathways, including the System Xc/GSH/GPX4 axis, the FSP1-CoQH system, and lipid metabolism networks, thereby dictating cellular susceptibility to ferroptotic stress
They do not compete for absorption and may actually support one another by protecting cells from oxidative stress and supporting healthy inflammatory responses
Science 367 , 10911097 (2020)
The abdomen was opened layer-by-layer to create a 2 cm wide opening
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