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Patients with chronic kidney disease (particularly non-dialysis CKD), liver conditions, or other metabolic disorders should consult their healthcare team before increasing protein intake, as individual requirements may differ substantially

A series of 10 phase 3 multicenter, randomized clinical studies as part of the Peptide InnOvatioN for Early diabetes tReatment (PIONEER) program were conducted to compare the efficacy and safety of oral semaglutide with either placebo or active comparators [2131]

Activation of the glucagon receptor with retatrutide is being investigated in a large phase 3 program that includes 14 trials and more than 22,000 participants

H., Rubino, D., Sbraccia, P., Wadden, T., Zeuthen, N., & Wilding, J