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During the development and maturation of pancreatic cells, key transcription factors include Pancreatic/duodenal homeobox 1 (Pdx1), neurogenin 3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) (Zhu et al., 2017)

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Gastrointestinal side effects caused 5.6% of semaglutide patients to stop their medication entirely, compared to only 2.7% of tirzepatide patients.[1] That's roughly half the dropout rate due to GI issues

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