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B.MieyalJ
As that cooler fluid enters the bloodstream, temperature sensors in the veins pick up the difference and create a cold sensation
In the GR-carmustine system (unsupported) the active site of the protein comprises of the residues Pro160, Ser161, Pro163, Ser177, Gly194, Gly196, Tyr197, Ala199, Ile198, Gly204, Trp287, Ala288, Ile289, Gly290 and Arg291, that play a key role in binding with the drug moiety as observed during docking and refined using QM/MM calculation
For these reasons, APE1 was considered to be a promising prognostic cancer biomarker and therapeutic target
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