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Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD ( p = 0.007), objective SCORAD ( p = 0.001), serum total IgE levels ( p = 0.005) and Childrens Sleep Habits Questionnaire scores ( p = 0.006) at 6 weeks (40)

The 11.2% discontinuation rate means roughly 1 in 9 people stop due to side effects

These hormonal shifts work together to support sustainable weight loss, stabilize blood sugar levels, and improve overall metabolic health

Interestingly, these effects were absent in female mice, suggesting potential sexual dimorphism in their responses to gut microbiome manipulation