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10.3390/ijms141021021 49

Further research suggests that AOD 9604 operates through the 3-adrenergic pathway, a receptor class known to mediate lipolytic responses in fat cells

"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here