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A board-certified Orthopaedic Surgeon in General and Sports Medicine, he served as Chief of Surgery at University Hospitals Conneaut Medical Center, Site Director of the University Orthopaedic Residency Program at University Hospitals, and Director of The Ohio Bone & Joint Institute
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Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)
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