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Further research is needed to determine whether sex hormones directly influence GLP-1R signaling in AgRP neurons or whether alternative pathways, such as differential engagement of reward circuits or peripheral metabolic adaptations, contribute to the observed differences
High-fat and greasy foods should be limited or avoided, especially during the initial weeks of therapy and after dose increases
Work schedule and lifestyle considerations are equally important
If the patient has vomiting/severe diarrhea on any regimen: Counsel that pill absorption may be compromised
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