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It used a ShapiroWilk test to assess normality and an F-test to assess homoscedasticity, and attempted log-transformation to resolve any lack thereof 40
A 2001 RCT by Nusgens and colleagues published in the Journal of Investigative Dermatology (N=33) used punch biopsy to demonstrate that topical vitamin C significantly increases mRNA levels of collagen I, collagen III, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the human dermis direct molecular evidence of collagen gene upregulation at the tissue level
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It is typically marketed online as a research chemical with disclaimers such as not for human consumption. Because of this classification, the quality, purity, and labeling of DSIP products can vary significantly between suppliers, and there are no standardized manufacturing or safety regulations in place
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