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Whilst some laboratory studies and small-scale human trials have suggested that certain probiotic strains may influence gut hormone levels, there is currently no robust clinical evidence demonstrating that probiotic supplements can reliably increase GLP-1 production or lead to clinically significant weight loss in humans
Figure 7: Photograph of Leonard Thompson in 1930 together with (A) his medical record and (B) chart of his blood sugar levels from December 1921 to January 1922 (credit:Thomas Fisher Rare Book Library, University of Toronto)
In select patientsparticularly those with obesity or metabolic syndromethis combo approach can enhance disease control, reduce flare frequency, and potentially decrease reliance on repeated antibiotic courses or escalating immunosuppressants
By injecting a small dose of prescribed Semaglutide GLP-1 into the upper arm, thigh, or abdomen, patients have reported themselves better at resisting their cravings, feeling satiated for longer periods of time, and that their energy levels feel more stable throughout the day
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