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Baker MA, Taub RN

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The six dysfunctional hormones of type 1 diabetes

PG004 Semaglutide biosimilar Pipeline Obesity and Diabetes Semaglutide Semaglutide Biosimilar A new game changer in the diabetes and obesity treatment market Features Next generation obesity and diabetes treatment based on GLP-1 analogue that lasts for one week Maintaining blood sugar through regulation of insulin and glucagon secretion Weight loss by suppressing appetite through nervous system Originator Mechanism Semaglutides core mechanism of action Its an analog of GLP-1(glucagon-like peptide-1) and activated the gastrointestinal hormone incretin to control blood sugar levels and reduce weight Obesity Semaglutide delays the rate at which food is expelled from the stomach and acts on the appetite center to suppress appetite and increase satiety, thereby reducing the amount of food consumed and resulting in weight loss Diabetes Semaglutide regulates blood sugar by stimulating pancreatic beta cells to increase insulin secretion and inhibiting glucagon secretion Alzheimer's Phase 3 clinical trials for Alzheimer's disease are currently underway Equivalence analysis results LC and MS analysis confirmed more than 99% similarity to the originator As a result of cAMP analysis using a GLP-1 recptor expressing cell line, it was confirmed to be more than 99% similar to the originator Semaglutide biosimilar research and development results As a result of the development of a semaglutide biosimilar, PEPGENE has completed the development of a biosimilar that is more than 99% similar to the original semaglutide