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Semaglutide (STEP 1 trial): Participants lost an average of 14.9% of body weight over 68 weeks at the 2.4 mg dose, compared to 2.4% with placebo
Sulfonylureas may need dose reduction during weeks 1 to 2 when overlapping drug levels increase hypoglycemia risk
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It mimics certain peptides found in the gut that support tissue repair 1 2
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