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Proper storage of compounded semaglutide in the refrigerator between 36F to 46F (2C to 8C) is important to ensure the medication remains effective and safe to use

Empower's semaglutide uses the same active ingredient but is a compounded formulation that includes added vitamins (cyanocobalamin or methylcobalamin) and has not been evaluated by the FDA for safety or efficacy

This may indicate that the association is not causal or that the effect is age-dependent (most of the cohort studies included older adults) or only observed in individuals with a more deficient B12 status

Renal function : Serum creatinine and estimated glomerular filtration rate (eGFR) should be monitored, especially in patients experiencing significant gastrointestinal adverse effects that may lead to dehydration