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In diet-induced obesity models, this inhibition has been observed to reduce white fat accumulation and promote lipolysis, effectively reprogramming metabolic pathways toward enhanced energy expenditure
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This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum ( Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases
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