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Bourdas DI, Souglis A, Zacharakis ED, Geladas ND, Travlos AK (2021) Meta-analysis of carbohydrate solution intake during prolonged exercise in adults: from the last 45+ years perspective

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However, clinical research increasingly recognized that patients with metabolic diseases frequently experience clusters of systemic complications, including heart failure (HF), chronic kidney disease (CKD), and fatty liver disease, that single-target drugs historically failed to address comprehensively

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