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Off-label use for obesity in non-diabetics does occur and shows modest benefit, but GLP-1 agonists are the preferred agents for primary weight loss in non-diabetics
References: Blundell, J., Finlayson, G., Axelsen, M., Flint, A., Gibbons, C., Kvist, T., & Hjerpsted, J
The most relevant weight-loss comparison is between tirzepatide and semaglutide at doses used for weight management, rather than Zepbound and Ozempic directly
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