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Superoxide dismutase (Cu/Zn-SOD), another copper-dependent enzyme, is the most important antioxidant enzyme in the cytoplasm

Glutathione does reduce oxidative stress markers (MDA, 4-HNE) during acute alcohol exposure, which theoretically lowers hepatocyte damage

In particular, lower levels of adiponectin and increased expression of TNF- and its soluble receptor have been recently related to the development of NASH ( Most patients with NAFLD are asymptomatic, and the diagnosis is mainly made incidentally on the basis of liver biochemistry or abdominal ultrasound abnormalities